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Close association of AFP level with HBV-DNA increase caused by lamivudine and adefovir resistance |
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Özcan Karaman, Mehmet Çölbay, Ihsan Uslan, Gursel Acarturk |
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ABSTRACT |
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Marked elevations in serum alpha fetoprotein (AFP) levels are highly suspicious for hepatocellular carcinoma and should prompt an extensive diagnosis. We report a case of chronic hepatitis B where episodes of marked elevations in serum AFP levels occurred, after viral breakthrough and acute exacerbation of hepatitis following development of lamivudine and adefovir resistance. The patient had a prompt improvement after adefovir and entacavir treatment, respectively. |
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Keywords |
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Alpha fetoprotein, chronic hepatitis B, lamivudine resistance, adefovir resistance, entecavir |
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